Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells
Abstract Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous sun decal for wall actin (F-actin) cytoskeleton.The exact extent of these effects on tumour-specific T cells are not completely understood.Here we demonstrate that Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-